Our main research interest is genes or factors that may play a role in prevention of tumors, such as hereditary polyposis or colon cancer. Current focus is on prostaglandin D2 as a tumor preventing molecule.
Other research activities are involved with genetic disorders, including malformation syndromes, inborn errors of metabolism, and other hereditary conditions.
- A.B., University of California, Berkeley
- M.D., Harvard Medical School, Boston, MA
- Professor of Pediatrics, David Geffen School of Medicine at UCLA and Harbor-UCLA Medical Center
Recent and/or Significant Studies:
- Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer. Tippin BL, Levine AJ, Materi AM, Song WL, Keku TO, Goodman JE, Sansbury LB, Das S, Dai A, Kwong AM, Lin AM, Lin JM, Park JM, Patterson RE, Chlebowski RT, Garavito RM, Inoue T, Cho W, Lawson JA, Kapoor S, Kolonel LN, Le Marchand L, Haile RW, Sandler RS, Lin HJ. Prostaglandins Other Lipid Mediat. 2012 Jan;97(1-2):22-8.
- High dietary niacin may increase prostaglandin formation but does not increase tumor formation in ApcMin/+ mice. Kwong AM, Tippin BL, Materi AM, Buslon VS, French SW, Lin HJ. Nutr Cancer. 2011;63(6):950-9.
- Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice. Park JM, Kanaoka Y, Eguchi N, Aritake K, Grujic S, Materi AM, Buslon VS, Tippin BL, Kwong AM, Salido E, French SW, Urade Y, Lin HJ. Cancer Res. 2007 Feb 1;67(3):881-9.